The present study brings together the bene ts of the results of exergy, exergoeconomic, and exergoenvironmental analyses as well as Optimization of a wasteto-energy power plant. First, exergoeconomic balance for each stream was calculated. To validate the current simulations, the actual data from the Amsterdam waste-to-energy power plant in working conditions were examined. Moreover, the behaviors of the in uential parameters in the objective functions were evaluated. In order to perform multi-objective Optimization, Multi-Objective Particle-Swarm Optimization ((MOPSO)) algorithm was employed. To obtain the optimum operating conditions, 14 design parameters and 3 objective functions were taken into consideration, with the total cost rate, total exergy e ciency of the cycle, and environmental impacts as the objective functions. Finally, the TOPSIS decision-making method determined the optimum-operating conditions. The results of exergy analysis indicated that the most exergy destruction belonged to the incinerator unit at 66%. Instead, the pumps contributed the least in this eld (approximately 1%). Under the in uence of the Optimization process, the total exergy e ciency of the power plant increased from 30. 89% to 38. 9% at the total cost of 5188. 05 USD/hour. A comparison of the obtained results from the Optimization procedure revealed that introducing optimum working condition would cause an increase in the exergy e ciency and a decrease in the exergy destruction among the components.